Profound methyl effects in drug discovery and a call for new C-H methylation reactions.

By Heike Schönherr, T. Cernak. Angewandte Chemie, 2013

802 citations recorded by the source corpus.

Subfields: Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/2ce00aab0c58a6acd16f5163194be323b1b9f92b

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In Organic Chemistry

1. John Karanicolas
2. David K. Johnson

Citations in the corpus

• Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations (2015, positive): “However, small changes to a compound can have profound effects on binding affinity (188, 189); as such, screening a complete library may yield hits from chemical series that may otherwise have been excluded”