Synthesis and characterization of biodegradable non-toxic poly(ester-urethane-urea)s based on poly(ε-caprolactone) and amino acid derivatives

By Á. Marcos‐Fernández, Gustavo A. Abraham, J. L. Valentín, J. S. Román. 2006

139 citations recorded by the source corpus.

Abstract Non-toxic biodegradable linear poly(ester-urethane-urea)s with different hydrophilic character were synthesized from poly(e-caprolactone) as macrodiol, l -lysine diisocyanate (LDI) and ethyl ester l -lysine or l -ornithine as chain extenders. Linear segmented polymers were synthesized by the prepolymer method with a tertiary amine playing a critical role in the chain extension in heterogeneous conditions. The prepared segmented polymers were fully chemically and physically characterized, including water uptake and hydrolytic stability measurements. Depending on the poly(e-caprolactone) length, the segmented polymers were amorphous or semicrystalline. The crystallinity degree strongly affected the mechanical properties and water uptake behaviour.

Subfields: Biomaterials, Organic Chemistry, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/2cd2d101a0a46b2eb44cfb2e7fe1f362b6fac903