Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
By Benjamin J. Raphael, R. Hruban, A. Aguirre, R. Moffitt, J. Yeh, Chip Stewart, A. G. Robertson, A. Cherniack, M. Gupta, Gad Getz and 256 more. Cancer Cell, 2017
1,688 citations recorded by the source corpus.
SUMMARY We performed integrated genomic, transcriptomic and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1 and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1 and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine.
Subfields: Cancer Research, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/2c4bbc1636a7915bb47677368ab580dc324f7812
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Oncology
In Surgery
Citations in the corpus
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer (2018, positive): “However, analysis of other related cancer types (high grade serous ovarian cancer 41 and pancreatic adenocarcinoma 42 ) found statistically significant increases in mortality associated with decreased METTL3 expression (Supplementary Fig.”