Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis.

By M. Machtay, J. Moughan, A. Trotti, A. Garden, Randal S. Weber, Jay S. Cooper, A. Forastiere, K. Ang. Journal of Clinical Oncology, 2008

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PURPOSE Concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN) increases both local tumor control and toxicity. This study evaluates clinical factors that are associated with and might predict severe late toxicity after CCRT. METHODS Patients were analyzed from a subset of three previously reported Radiation Therapy Oncology Group (RTOG) trials of CCRT for locally advanced SCCHN (RTOG 91-11, 97-03, and 99-14). Severe late toxicity was defined in this secondary analysis as chronic grade 3 to 4 pharyngeal/laryngeal toxicity (RTOG/European Organisation for the Research and Treatment of Cancer late toxicity scoring system) and/or requirement for a feeding tube >or= 2 years after registration and/or potential treatment-related death (eg, pneumonia) within 3 years. Case-control analysis was performed, with a multivariable logistic regression model that included pretreatment and treatment potential factors. RESULTS A total of 230 patients were assessable for this analysis: 99 patients with severe late toxicities and 131 controls; thus, 43% of assessable patients had a severe late toxicity. On multivariable analysis, significant variables correlated with the development of severe late toxicity were older age (odds ratio 1.05 per year; P = .001); advanced T stage (odds ratio, 3.07; P = .0036); larynx/hypopharynx primary site (odds ratio, 4.17; P = .0041); and neck dissection after CRT (odds ratio, 2.39; P = .018). CONCLUSION Severe late toxicity after CCRT is common. Older age, advanced T-stage, and larynx/hypopharynx primary site were strong independent risk factors. Neck dissection after CCRT was associated with an increased risk of these complications.

Subfields: Otorhinolaryngology, Surgery

View Paper: https://www.semanticscholar.org/paper/2c0500c35c87aff6f4de3b2216a63cc8ffdb67b2

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Citations in the corpus

Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “The response rate was found to be >70% without observation of severe toxicities [104], whereas severe side effects occurred when un-encapsulated chemotherapeutics were combined with radiotherapy [105,106].”
An update on larynx cancer (2017, methodology): “A secondary analysis of concurrent CRT trials, including RTOG 91-11, 97-03, and 99-14, examined late toxicity.(70) In cancer-free survivors, the rate of late toxicities reached 43%.”
Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis (2017, background): “Increasing age is associated with increased risk of severe late toxicity, such as dysphagia, aspiration pneumonia, and longterm feeding tube dependence on prospective RTOG protocols [96].”
Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand? (2017, background): “Indeed swallowing disorders, chronic pain and osteoradionecrosis, that have major impact on quality of life, can occur up to 5–10 years after chemoradiation completion [33].”