Statistical factors involved in neuromuscular facilitation and depression

By J. Castillo, B. Katz. 1954

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Short-term presynaptic plasticity. (2012, background): “…sustained high-frequency activation eventually results in profound depression, and recovery from this depression is much slower (many tens of seconds) than for pairedpulse depression (seconds) (Eccles and O’Connor 1941; Feng 1941; del Castillo and Katz 1954; Betz 1970; Thomson et al. 1993).”
A History of Spike-Timing-Dependent Plasticity (2011, background): “Sir Bernard Katz (Figure 7), a student of Eccles, took the study of short-term plasticity in a statistical direction to better understand its mechanisms (Del Castillo and Katz, 1954), which gave rise to the quantal hypothesis of neurotransmitter release.”
Short-term synaptic plasticity. (2002, background): “At neuromuscular junctions, an AP can cause facilitation equally well, even if transmitter release does not occur (20, 21); therefore, facilitation seems to arise from some process following AP invasion but preceding secretion.”