Autonomic regulation of islet hormone secretion – Implications for health and disease

By B. Ahrén. Diabetologia, 2000

833 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Peptide agonists including somatostatin, norepinephrine, and galanin inhibit insulin secretion through the activation of pertussis toxin (PTX)-sensitive G protein Gi/o (3, 497, 595, 596).”
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development (2007, background): “Glucose-stimulated insulin secretion (GSIS) is regulated by numerous hormones and neurotransmitters most of which act on specific GPCRs expressed by pancreatic β-cell”
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. (2011, background): “This result was unexpected, considering the classically described role of vagal efferent stimulation of the pancreas as a stimulatory signal for insulin secretion (Ahren, 2000).”
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “A dense meshwork of sensory nerve fibres is found in the pancrea”