The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.

By E. V. Allen, N. Wagle, A. Sucker, D. Treacy, Cory M. Johannessen, Eva M. Goetz, Chelsea S. Place, A. Taylor-Weiner, S. Whittaker, G. Kryukov and 22 more. Cancer Discovery, 2014

705 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2b7e554eb98fdbea1b4918c78694d1976e202bab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. Christopher Sander
2. Matthew Meyerson
3. Nikolaus Schultz

In Molecular Biology

1. Peter W. Laird
2. S. Baylin
3. Eric S. Lander
4. Manel Esteller
5. Timothy Triche
6. Katherine A. Hoadley
7. J. Herman
8. Gad Getz

In Pathology and Forensic Medicine

1. John N. Weinstein
2. Peter W. Laird
3. David Haussler
4. S. Baylin

Citations in the corpus

• Genomic Classification of Cutaneous Melanoma (2015, positive): “The RAC1 hot-spot mutation has been linked to resistance to BRAF inhibitors (Van Allen et al., 2014; Watson et al., 2014).”
• Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. (2014, neutral): “Increased creatine kinase 6 (3) 1 (<1) 0 0 23 (9) 27 (11) 17 (7) 9 (4)”