Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.

By D. Keh, T. Boehnke, Steffen Weber-Cartens, C. Schulz, O. Ahlers, S. Bercker, H. Volk, W. Doecke, K. Falke, H. Gerlach. American Journal of Respiratory and Critical Care Medicine, 2003

598 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/2b5d090a5b0a5318d893202af54b265b3ba833d0

How researchers see this paper

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In Endocrinology, Diabetes and Metabolism

1. G. Ramsay
2. A. Rhodes
3. Laura Evans
4. Jean-Louis Vincent
5. Derek C. Angus
6. Janice L. Zimmerman
7. Mitchell M. Levy
8. R. Dellinger

In Epidemiology

1. Jean-Louis Vincent
2. Mitchell M. Levy
3. Derek C. Angus
4. Mervyn Singer
5. A. Rhodes
6. Laura Evans
7. G. Ramsay
8. Janice L. Zimmerman

Citations in the corpus

• Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2007, background): “One crossover study showed hemodynamic and immunologic rebound effects after abrupt cessation of corticosteroids (110).”
• Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine (2008, background): “Abruptly stopping hydrocortisone will likely result in a rebound of proinflammatory mediators, with recurrence of the features of shock (and tissue injury) (105, 119).”
• Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. (2005, background): “Likewise, in patients with septic shock, studies have shown that hydrocortisone infusion led to a significant reduction in circulating levels of NF-B–transcribed proteins (phospholipase A2, IL-6, IL-8, and soluble E-selectin) and CRP, while after withdrawal of treatment a rebound effect was observed”
• Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock (2004, background): “One study showed hemodynamic and immunologic rebound effects after abrupt cessation of corticosteroids (46).”
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “One crossover study showed hemodynamic and immunologic rebound effects after abrupt cessation of corticosteroids (312).”
• Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 (2013, background): “One crossover study showed hemodynamic and immunologic rebound effects after abrupt cessation of corticosteroids [188].”