Molecular Origins of Cancer

By S. Markowitz, M. Bertagnolli. New England Journal of Medicine, 2009

1,700 citations recorded by the source corpus.

This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.

Subfields: Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2b3fdf6f6a4d40edcb54af894a60a1e16b91da2d

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In Pathology and Forensic Medicine

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Citations in the corpus

• Dependency of colorectal cancer on a TGF-beta-driven programme in stromal cells for metastasis initiation (2012, background): “Hence, it has been proposed that TGF-b imposes a selective pressure during CRC progression, which tumors avert by genetic inactivation of the TGF-b receptors (TGFBR1 and TGFBR2) or of the SMAD intracellular mediators (SMAD4, SMAD2, and SMAD3) (Grady and Markowitz, 2002; Markowitz et al., 1995; Marko”
• Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions (2013, methodology): “We applied a two-step classification strategy: (i) out of the total 90 samples, 25 were classified to be CCS2 based on their microsatellite status (MSI); and (2) we used 44 MSS samples of CCS1 and 20 MSS samples of CCS3 to train a classifier using random-forest algorithm43 (R package randomForest, v”