Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

By Karoline B. Kuchenbaecker, J. Hopper, Daniel R. Barnes, K. Phillips, T. Mooij, M. Roos-Blom, Sarah Jervis, F. V. van Leeuwen, R. Milne, N. Andrieu and 50 more. Journal of the American Medical Association (JAMA), 2017

2,592 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/2b3250647b5765acc6425bba0f5022b25e30e038

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Siegel
2. K. Miller
3. A. Jemal

In Genetics

1. Lindsey A. Torre
2. A. Jemal
3. R. Siegel

In Oncology

1. R. Siegel
2. A. Jemal
3. K. Miller
4. C. DeSantis
5. Lindsey A. Torre
6. H. Salehiniya
7. Zohre Momenimovahed
8. F. Bray

Citations in the corpus

• DeepMiner: Discovering Interpretable Representations for Mammogram Classification and Explanation (2018, background): “Mutations in BRCA1 and BRCA2 are associated with an estimated life-time risk of breast cancer of approximately 70 percent (Kuchenbaecker et al., 2017), and patients carrying these mutations are recommended annual contrast-enhanced breast MRI exams in addition to screening mammography as well as the…”
• Epidemiological characteristics of and risk factors for breast cancer in the world (2019, background): “Based on a prospective cohort study, the risk of cumulative breast cancer by the age 80 years was 72% in the carriers of BRCA1 mutation (95% CI, 65%–79%), and this amount was 69% in the carriers of BRCA2 mutation (95% CI, 61%–77%).(77) Changes in human interferon α-2b may be involved in the onset an”
• Ovarian Cancer Statistics, 2018 (2018, background): “Among women with BRCA1 or BRCA2 mutations, the risk of developing ovarian cancer by age 80 years is 44% and 17%, respectively.(62) While these mutations are rare in the general population (less than 1%), they are more common in certain ethnic or geographically isolated groups, such as those of Ashke”