Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device
By N. Jeon, H. Baskaran, S. Dertinger, George M. Whitesides, L. Water, Mehmet Toner. Nature Biotechnology, 2002
925 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Immunology and Allergy, Oncology
View Paper: https://www.semanticscholar.org/paper/2b00b6f41df99588a0fed5492a976e6f717fd3bd
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In Biomedical Engineering
- C. Hansen
- Stephen R. Quake
- David J. Beebe
- J. El-Ali
- Klavs F. Jensen
- Peter K. Sorger
- Andrew deMello
- J. Atencia
In Oncology
Citations in the corpus
- Control and detection of chemical reactions in microfluidic systems (2006, background): “Crucially, although microfluidic systems have been shown to be highly effective at generating conditions in which variables such as reagent concentratio”
- Controlled microfluidic interfaces (2005, methodology): “In contrast to the concentration gradients produced with conventional methods, the profile in this microfluidic system is stable and can be maintained over long periods — characteristics that make the system attractive for studying processes that require gradients, such as chemotaxi”
- Engineering microfluidic concentration gradient generators for biological applications (2013, neutral): “…operation characteristics of some convection-based and diffusion-based gradient generators used in biological studies such as chemotaxis assays (Jeon, Baskaran et al. 2002; Lin, Nguyen et al. 2004; Abhyankar, Toepke et al. 2008; Kothapalli, van Veen et al. 2011) , migration/ wound-healing…”
- Microfluidics in structural biology: smaller, faster ... better (2003, methodology): “By creating networks of these diffusive contacts, this controlled mixing may be used to generate complex and temporally stable gradients [17]; these gradients have proved useful in the study of chemotaxis [18 ,19].”
- Cells on chips (2006, background): “The diffusive mixing properties of laminar flow created by microfluidics can also be used to create complex concentration gradients not achievable on a macroscal”