Targeting mutant p53 for efficient cancer therapy

By V. Bykov, S. Eriksson, Julie Bianchi, K. Wiman. Nature Reviews. Cancer, 2017

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The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “In addition, p53 also plays an important role in cell metabolism by inhibiting glycolysis and promoting oxidative phosphorylation in response to nutrient stimulation.(214,215) Under the stimulation of low carcinogenicity and genotoxicity, p53 is persistently expressed, but its protein level is often”
Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “3,4 p53 protein functions primarily as a transcription factor, which regulates a wide variety of pathways, such as cell cycle arrest, DNA repair, cell apoptosis, autophagy, and metabolism, 1,5,6 and determines whether cells die under stress conditions.”