Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.
By S. Hayashi, Andrew P. McMahon. Developmental Biology, 2002
1,411 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/2aa67cb9df3665ab2bfd70d0138ad99179018ef7
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In Immunology
In Molecular Biology
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In Public Health, Environmental and Occupational Health
Citations in the corpus
- A highly efficient recombineering-based method for generating conditional knockout mutations. (2003, background): “The timing of Cre expression can also be controlled using inducible Cre expression systems (Hayashi and McMahon 2002) or viral delivery systems such as adenovirus or lentivirus (Shibata et al.”
- Cells of origin in cancer (2011, background): “For example, a tamoxifen-inducible Cre recombinase–oestrogen receptor fusion protein (CreER”
- Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (2006, methodology): “Generation of nestin-creERtm Mice Nestin-CreERtm DNA construct was made by replacing Cre coding sequence in pNesCre (Tronche et al., 1999) with CreERtm from pBSCreERtm (Hayashi and McMahon, 2002).”
- ADAR1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs (2014, methodology): “ADAR1 iKO mice were prepared by crossing floxed ADAR1 mice (31) and Cre-ER transgenic mice (32) as described previously (19).”
- A global double‐fluorescent Cre reporter mouse (2007, background): “4h,i), due to the rapid onset of mG labeling within 24 h following Cre induction (data not shown; Hayashi and McMahon, 2002) and the perdurance of mT mRNA and protein.”
- Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis (2014, background): “In these experiments, the appearance of the reporter is detected at approximately 12 hr after the injection and these cells continue to accumulate for about 36 hr (Hayashi and McMahon, 2002).”
- The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium (2009, neutral): “In CreER/LoxP lineage-tracing studies, recombination of the floxed reporter allele is dependent on the dose of tamoxifen (tmx) and occurs stochastically in a fraction of the cells that express Cre (Hayashi and McMahon, 2002).”
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver (2010, methodology): “Mice were subsequently bred to albumin-cre (10), MMTV-cre (11), and Caggs-creER(T2) (12) mice followed by backcrossing to homozygous floxed animals.”