Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
By A. Sottoriva, I. Spiteri, S. Piccirillo, Anestis Touloumis, V. Collins, John C. Marioni, C. Curtis, C. Watts, Simon Tavaré. Proceedings of the National Academy of Sciences of the United States of America, 2013
1,701 citations recorded by the source corpus.
Subfields: Cancer Research, Cell Biology, Genetics
View Paper: https://www.semanticscholar.org/paper/2a62cb3f60b2d8a42a5e14a04947c6c4a64ae7c2
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- J. Reis-Filho
- T. Hunter
- Aviv Regev
- Niko Beerenwinkel
- Moritz Gerstung
- D. Louis
- Kenneth D. Aldape
- I. Stamenkovic
In Cell Biology
In Genetics
- J. Reis-Filho
- T. Hunter
- Aviv Regev
- Marco A. Marra
- Florian Markowetz
- Roland F. Schwarz
- Niko Beerenwinkel
- Moritz Gerstung
Citations in the corpus
- Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma (2013, background): “In addition, tumor evolutionary dynamics have been shown in a recent report wherein multiple transcriptome signatures were found within the same tumor (Sottoriva et al., 2013).”
- A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity (2015, neutral): “Page 2 particularly the drivers, are present in 30%-80% of cells in the primary tumor as well as in metastatic lesions derived from it [2,3,4,5].”
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma (2014, background): “Glioblastoma is an archetypal example of a heterogeneous cancer and one of the most lethal human malignancies (9, 10).”
- Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma (2015, background): “Given that LC was confirmed at the autopsy of BMBC2, our results indicated that the CSF Genev Amino acid BM (1) BM (2) BM (3) Liver (1) Liver (2) Liver (3) Liver (4) Liver (5) Liver (6) Gastric CSF ctDNA Plasma ctDNA TBX3 K137fs TP53 P177fs MAP2K4 E372X NCOR1 R507X ASXL2 A1269I FLT3 T820S MET N1081H”
- Cancer Evolution: Mathematical Models and Computational Inference (2014, methodology): “TuMult has been applied by Sottoriva et al. (2013a) to estimating phylogenies of glioblastoma.”
- Mutational Analysis Reveals the Origin and Therapy-driven Evolution of Recurrent Glioma (2013, neutral): “Many solid tumors, including glioblastoma (GBM) display intratumoral heterogeneity (17, 18).”