Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

By Liming Nie, Xiaoyuan Chen. Chemical Society Reviews, 2014

307 citations recorded by the source corpus.

Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensive research has been focused on developing new contrast agents to improve the imaging sensitivity, specificity and efficiency. These emerging materials have substantially accelerated PAT applications in signal sensing, functional imaging, biomarker labeling and therapy monitoring etc. Here, the potentials of different optical probes as PAT contrast agents were elucidated. We first describe the instrumental embodiments and the measured functional parameters, then focus on emerging contrast agent-based PAT applications, and finally discuss the challenges and prospects.

Subfields: Biomedical Engineering, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/2a4317e3a645bf0e6a59644fc24887e0e756b66e

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In Biomedical Engineering

Citations in the corpus

Model-Based Learning for Accelerated, Limited-View 3-D Photoacoustic Tomography (2017, background): “Photoacoustic Tomography (PAT) is an emerging ”Imaging from Coupled Physics” technique [1] that can obtain high resolution 3D in-vivo images of absorbed optical energy by sensing laser-generated ultrasound (US) [2], [3], [4], [5], [6], [7].”