An anorexic lipid mediator regulated by feeding

By F. Fonseca, M. Navarro, R. Gómez, L. Escuredo, F. Nava, Jin Fu, Eric Murillo-Rodríguez, A. Giuffrida, J. Loverme, S. Gaetani and 3 more. Nature, 2001

728 citations recorded by the source corpus.

Oleylethanolamide (OEA) is a natural analogue of the endogenous cannabinoid anandamide. Like anandamide, OEA is produced in cells in a stimulus-dependent manner and is rapidly eliminated by enzymatic hydrolysis, suggesting a function in cellular signalling. However, OEA does not activate cannabinoid receptors and its biological functions are still unknown. Here we show that, in rats, food deprivation markedly reduces OEA biosynthesis in the small intestine. Administration of OEA causes a potent and persistent decrease in food intake and gain in body mass. This anorexic effect is behaviourally selective and is associated with the discrete activation of brain regions (the paraventricular hypothalamic nucleus and the nucleus of the solitary tract) involved in the control of satiety. OEA does not affect food intake when injected into the brain ventricles, and its anorexic actions are prevented when peripheral sensory fibres are removed by treatment with capsaicin. These results indicate that OEA is a lipid mediator involved in the peripheral regulation of feeding.

Subfields: Cognitive Neuroscience, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/29fd4f7d2e63f5a1925a9868de03d2eb27f5fb93

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In Cognitive Neuroscience

Daniele Piomelli

In Pharmacology

Citations in the corpus

The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide (2005, methodology): “We have recently shown that OEA, a lipid amide structurally related to PEA, elicits satiety and stimulates lipolysis in rodents by activating the nuclear receptor PPAR- (Rodrı́guez de Fonseca et al., 2001; Fu et al., 2003; Guzman et al., 2004).”
The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “Another endogenous lipid, a monounsaturated fatty acid ethanolamide, named oleoylethanolamide (OEA), was recently proposed as an important modulator of food intake (317).”