Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past
By D. Giannis, I. Ziogas, Panagiota Gianni. Journal of Clinical Virology, 2020
827 citations recorded by the source corpus.
Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus strain disease, has recently emerged in China and rapidly spread worldwide. This novel strain is highly transmittable and severe disease has been reported in up to 16% of hospitalized cases. More than 600,000 cases have been confirmed and the number of deaths is constantly increasing. COVID-19 hospitalized patients, especially those suffering from severe respiratory or systemic manifestations, fall under the spectrum of the acutely ill medical population, which is at increased venous thromboembolism risk. Thrombotic complications seem to emerge as an important issue in patients infected with COVID-19. Preliminary reports on COVID-19 patients’ clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation. As the pandemic is spreading and the whole picture is yet unknown, we highlight the importance of coagulation disorders in COVID-19 infected patients and review relevant data of previous coronavirus epidemics caused by the severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
Subfields: Infectious Diseases, Oncology
View Paper: https://www.semanticscholar.org/paper/29fbdbdcbdcb86460d90fb939d6df76896f3316f
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Citations in the corpus
- A brief review of socio-economic and environmental impact of Covid-19 (2020, background): “…with a limited number of people benefiting from this scenario. c. Official regulations to avoid going out can be counterproductive for densely populated areas. d. Patients already suffering from chronic illnesses are at higher risk than healthy people (Giannis et al. 2020; Zheng et al. 2020). e.”
- Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 (2020, background): “In particular, coronavirus infections may be a trigger for venous thromboembolism, and several pathogenetic mechanisms are involved, including endothelial dysfunction, characterized by increased levels of von Willebrand factor; systemic inflammation, by Toll-like receptor activation; and a procoagul”