Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus

By Y. Lo, K. C. Chan, Hao Sun, Eric Z. Chen, P. Jiang, Fiona M. F. Lun, Yama W. L. Zheng, T. Leung, T. Lau, Charles R. Cantor and 1 more. Science Translational Medicine, 2010

1,030 citations recorded by the source corpus.

Subfields: Cancer Research, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/29eeeee9cd2087070da7c53253c3ca9ca054731f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Jay Shendure
2. Daniel C. Koboldt
3. Elaine R. Mardis
4. Jerzy K. Kulski

Citations in the corpus

• Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients (2015, methodology): “In pregnant women, plasma DNA derived from the fetus has been shown to be shorter than that of DNA derived from the mother (28).”
• The Next-Generation Sequencing Revolution and Its Impact on Genomics (2013, positive): “In 2010, Lo et al. sequenced maternal plasma genomic DNA to 653 coverage and then used the parental SNP genotypes (from SNP array data) to distinguish fetal versus maternal sequencing reads (Lo et al., 2010).”
• Fragment Length of Circulating Tumor DNA (2016, result): “previously reported similar findings from maternal serum with regards to fragment length differences between fetal cell-free DNA and maternal cell-free DNA [27].”
• Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin (2016, positive): “These distributions support a model in which cfDNA fragments are preferentially protected from nuclease cleavage by association with proteins—in this case, by the nucleosome core particle (NCP) and linker histone—but where some degree of additional nicking or cleavage occurs in relation to the helic”