Role of C5a in inflammatory responses.

By R. Guo, P. Ward. Annual Review of Immunology, 2005

1,061 citations recorded by the source corpus.

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Citations in the corpus

The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “Anaphylatoxins in acute and chronic inflammation ATs have been shown to promote inflammatory responses during the effector phase of allergic, infectious and autoimmune diseases (reviewed in (Guo and Ward, 2005;Köhl, 2001)).”
A Review of SARS-CoV-2 and the Ongoing Clinical Trials (2020, background): “The role of C5a includes recruitment of neutrophils and T-lymphocytes, and increasing pulmonary vascular permeability [74].”
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis (2018, background): “C3a and C5a in particular are noted for their roles in causing mast cell degranulation, initiating a cytokine storm, promoting vascular permeability, and contributing to acute lung injury (36, 49, 50).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “C5a, also known as anaphylatoxin, and C3a have inherent inflammatory activity, are chemoattractants, and localize to endothelial cells within solid tumors (97, 98).”
Modulation of the anti-tumor immune response by complement (2008, background): “The ensuing deposition of the C5b fragment on the cell surface contributes to the formation of the pore-like membrane attack complex (MAC) in cellular membranes, whereas the anaphylatoxin C5a is released and acts as an even more potent chemoattractant and inflammatory mediator than C3”
Complement and coagulation: strangers or partners in crime? (2007, background): “These complex and reciprocal interactions also have a role in the pathogenesis of several diseases, and, in some situations, they lead to life-threatening complications, such as thrombosis (the formation of multiple thrombi) in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) [”
Generation of C5a in the absence of C3: a new complement activation pathway (2006, methodology): “We induced lung injury in mice using previously described method”
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. (2011, background): “Additional criteria that were considered somewhat relevant for the measurement of ALI included measurements of procoagulant activity (52), expression of adhesion molecules (53), conversion of the neutrophilic alveolitis to a monocytic alveolitis with time, and elevations in the levels of specific co”