Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

By C. Haiman, Gary K. Chen, William J Blot, Sara S. Strom, S. Berndt, Rick Kittles, B. Rybicki, William B. Isaacs, S. Ingles, Janet L. Stanford and 52 more. 2011

213 citations recorded by the source corpus.

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10−13). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Subfields: Genetics, Pulmonary and Respiratory Medicine

Citations in the corpus

• International variation in prostate cancer incidence and mortality rates. (2012, unknown): “…such as variants in alleles on chromosomes including (but not limited to) 8q24 and 17q21 may be specific to men of African descent [41] [42] [43] in the United States and elsewhere, suggesting that the PCa disparity by race may partly be due to variations in genetic Table 2 – Trends in…”