Preterm Labor: One Syndrome, Many Causes
By Roberto Romero, S. Dey, S. Fisher. Science, 2014
1,824 citations recorded by the source corpus.
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.
Subfields: Epidemiology, Immunology, Obstetrics and Gynecology
View Paper: https://www.semanticscholar.org/paper/29d6e76251156a9eb04242d255946eac38ff9790
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In Epidemiology
Citations in the corpus
- Temporal and spatial variation of the human microbiota during pregnancy (2015, background): “Approximately 25% of preterm births are associated with occult microbial invasion of the amniotic cavity (5).”