Salience processing and insular cortical function and dysfunction

By Lucina Q. Uddin. Nature Reviews Neuroscience, 2014

1,962 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/29cc24c09fd945995adda417358f366c7790915c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

Citations in the corpus

Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education (2019, positive): “Critically, the Default Mode Network is recruited when task-oriented, goal-directed behavior and externally directed attention and perception are attenuated; it does not readily coactivate with the Executive Control Network.”
Why fish do not feel pain (2016, background): “This behaviour involves a complex coordination of hip, knee and ankle joint movements that are not stereotyped since joint kinematics vary as the paper is shifted to different parts of the body.”
Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks (2019, positive): ““The anterior insular cortex is thought to be a key node of a salience network that also includes the dorsal anterior cingulate cortex and other subcortical and limbic structures” (Uddin 2015).”
Insects have the capacity for subjective experience (2016, background): “Together, these results suggest that the insular cortex plays an important integrative function in the neural processing associated with the sensation of pain and other salient stimuli (Uddin, 2015).”
Childhood Adversity and Neural Development: A Systematic Review (2019, background): “…of emotional processing following adversity have focused on amygdala function, a network of regions extending beyond the amygdala responds to stimuli that have motivational salience; this network includes the anterior insula, dACC, and supplementary motor area (Seeley et al. 2007, Uddin 2015).”
From cognitivism to autopoiesis: towards a computational framework for the embodied mind (2016, background): “…response inhibition) and affective (emotion regulation and awareness) conditions and sends projections to the parietal-frontal control regions and brainstem nuclei (Allen et al. 2016a; Cerliani et al. 2012; Klein et al. 2013; Uddin 2015), with both proﬁles being freely mixed in the middle insula.”
Multi-task Intracranial EEG recordings reveal a Comprehensive Role of the Human Dorsal Anterior Insula in High-Level Cognition (2025, unknown): “…saliency detection), others have suggested a more active role in the initiation and the orchestration of the cognitive response to selected stimuli ( Dosenbach et al. ( 2008 ); Dosenbach et al. ( 2025 ); Menon ( 2011 ); Menon et al. ( 2020 ); Molnar-Szakacs and Uddin ( 2022 ); Uddin ( 2015 )).”
Slow neural oscillations explain temporal fluctuations in distractibility (2023, background): “Specifically, the insular cortex may support the switching between networks important to internally directed and externally directed cognition, respectively (Uddin, 2015).”