The role of engram cells in the systems consolidation of memory
By S. Tonegawa, Mark D. Morrissey, T. Kitamura. Nature Reviews Neuroscience, 2018
385 citations recorded by the source corpus.
What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain. Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss recent advances in our understanding of the contribution of engram cells to this process.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/29c6b36d02ca4c7d22f8c1b06fc478b133205ae5
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
- Sheena A. Josselyn
- S. Tonegawa
- Steven C. H. Hoi
- Douglas A. Baxter
- John H. Byrne
- Paul Smolen
- Chenghao Liu
- Quang Pham
Citations in the corpus
- Memory engrams: Recalling the past and imagining the future (2020, background): “Systems consolidationwas recently examined at the level of the engram in the hippocampus and mPFC, where findings indicate time-dependent silencing of active engrams and conversions of silent engrams to active engrams (51, 199).”
- Continual Learning, Fast and Slow (2021, background): “1 Particularly, the hippocampus focuses on fast learning of pattern-separated representation of specific experiences [7], [8].”
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “Properties of engrams have recently been further reviewed (Josselyn et al. 2017; Tonegawa et al. 2018).”