Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms.

By C. Linde, W. Abraham, M. Gold, M. G. St. John Sutton, S. Ghio, C. Daubert. Journal of the American College of Cardiology, 2008

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ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 (2012, result): “These findings are supported by echocardiographic analyses.(161) For these reasons, in patients with milder symptoms, CRT is recommended only in those with either a QRS duration ≥150 ms or ≥130 ms plus an LBBB pattern.”
2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). (2013, methodology): “Pre-speciﬁed subgroup analyses of data collected in the MADIT-CRT, REVERSE and Resynchronization–Deﬁbrillation for Ambulatory Heart Failure Trial (RAFT) trials demonstrated that patients with a QRS duration ≥ 150 ms beneﬁted most from CRT. 50,61,62 Meta-analyses using aggregate data from randomized ”