Role of tumor microenvironment in tumorigenesis
By Maonan Wang, Jing-zhou Zhao, Lishen Zhang, F. Wei, Yu Lian, Yingfen Wu, Zhaojian Gong, Shanshan Zhang, Jianda Zhou, K. Cao and 5 more. Journal of Cancer, 2017
1,196 citations recorded by the source corpus.
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/299dd34db5e33d7c979937c6c6409c301c71d58d
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Citations in the corpus
- ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “The tumor microenvironment plays an essential role in tumor initiation, progression, and metastasis [258].”
- Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “The tumor heterogeneity is exacerbated during the progression of the cancer along with the maturation of the cellular and noncellular components of the tumor niche—the tumor microenvironment (TME) [4,5].”
- Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “In the development and progression of tumors, many signaling pathways are involved in controlling cell growth and proliferation, apoptosis and viability, and can participate in more complex signaling networks that contribute to tumor progression, such as tumor microenvironment (TME), angiogenesis an”