SOCS Regulation of the JAK/STAT Signalling Pathway
By B. Croker, Hiu Kiu, S. Nicholson. Seminars in Cell and Developmental Biology, 2008
637 citations recorded by the source corpus.
The Suppressor Of Cytokine Signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology.
Subfields: Cancer Research, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/299b6914fd0401e92f149e46f4207d3b8567cd38
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In Cancer Research
Citations in the corpus
- Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance (2010, background): “Impairment of growth hormone axis SOCs are known to interfere with growth hormone (GH) signaling (Croker et al. 2008).”