Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

By D. Newman. Journal of Medicinal Chemistry, 2008

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Natural products and drug discovery (2009, background): “Newman (2008) estimates that about 60% of the drugs that are now available—including household names such as artemisinin, camptothecin, lovastatin, maytansine, paclitaxel, penicillin, reserpine and silibinin—were either directly or indirectly derived from natural products.”
A Historical Overview of Natural Products in Drug Discovery (2012, background): “At the time, combinatorial libraries consisted of hundreds to thousands of new compounds, but during the late 1990s synthetic chemists realized that these libraries lacked the complexity of the intricate natural products synthesized by nature [123].”
Natural products in drug discovery. (2008, background): “Natural products have inspired many developments in organic chemistry [35, 36 ], leading to advances in synthetic methodologies and to the possibility of making analogues of the original lead compound with improved pharmacological or pharmaceutical properties [37].”