Etiopathogenesis of osteoarthritis.

By Kenneth D Brandt, Paul Dieppe, Eric L Radin. The Medical clinics of North America, 2009

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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes (2013, background): “OA is a progressive degenerative joint disease with different etiologies, and multifaceted risk factors have been suggested for the onset of OA, which include genetic predisposition, gender, aging, obesity, physical activity, previous joint injury, joint malalignment and abnormal joint shape [24].”
Cartilage homeostasis in health and rheumatic diseases (2009, background): “Differences in the morphologies of zonal subpopulations of chondrocytes may reflect matrix composition and are ascribed largely to differences in the mechanical environment [14].”