The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends

By D. Youlden, S. Cramb, P. Baade. Journal of Thoracic Oncology, 2008

818 citations recorded by the source corpus.

This review presents the latest available international data for lung cancer incidence, mortality and survival, emphasizing the established causal relationship between smoking and lung cancer. In 2002, it was estimated that 1.35 million people throughout the world were diagnosed with lung cancer, and 1.18 million died of lung cancer—more than for any other type of cancer. There are some key differences in the epidemiology of lung cancer between more developed and less developed countries. In more developed countries, incidence and mortality rates are generally declining among males and are starting to plateau for females, reflecting previous trends in smoking prevalence. In contrast, there are some populations in less developed countries where increasing lung cancer rates are predicted to continue, due to endemic use of tobacco. A higher proportion of lung cancer cases are attributable to nonsmoking causes within less developed countries, particularly among women. Worldwide, the majority of lung cancer patients are diagnosed after the disease has progressed to a more advanced stage. Despite advances in chemotherapy, prognosis for lung cancer patients remains poor, with 5-year relative survival less than 14% among males and less than 18% among females in most countries. Given the increasing incidence of lung cancer in less developed countries and the current lack of effective treatment for advanced lung cancers, these results highlight the need for ongoing global tobacco reform to reduce the international burden of lung cancer.

Subfields: Oncology, Pulmonary and Respiratory Medicine

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Citations in the corpus

Global cancer statistics, 2012 (2015, background): “In contrast, in countries where the epidemic has been established more recently and smoking has just peaked or continues to increase, such as China, Indonesia, and several countries in Africa, lung cancer rates are likely to continue to increase at least for the next few decades, barring interventio”
Global Epidemiology of Lung Cancer (2019, background): “Likewise, in the Russian Federation, all-cause mortality in men is largely attributed to very high rates (60”
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Cisplatin: The first metal based anticancer drug. (2019, background): “One of the most common fatal malignancies is lung cancer [100].”
Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap) (2013, background): “Non small-cell lung cancer (NSCLC) accounts for ∼85% of primary lung cancers, the most common subtypes being adenocarcinoma (ADC) and squamous cell carcinoma (SCC) [1].”