Fulminant Clostridium difficile: An Underappreciated and Increasing Cause of Death and Complications

By R. Dallal, B. Harbrecht, Arthur J Boujoukas, C. Sirio, L. Farkas, Kenneth K. Lee, R. Simmons. Annals of Surgery, 2002

639 citations recorded by the source corpus.

Subfields: Epidemiology, Gastroenterology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/284a27c693d5f516bfb1b31bbba40389dc9141b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. E. Dubberke
2. J. H. Morse

In Gastroenterology

1. J. Bartlett

In Infectious Diseases

1. J. Bartlett
2. Louis Valiquette
3. J. Pépin
4. Benoît Cossette
5. J. H. Morse

Citations in the corpus

• Mortality attributable to nosocomial Clostridium difficile–associated disease during an epidemic caused by a hypervirulent strain in Quebec (2005, background): “A lingering question that remains unanswered is why this strain of C. difficile spread so extensively within and between hospitals in Quebec, while dissemination of the same hypervirulent, and presumably highly infectious, strain seems to have been more limited in the rest of Canada and the United S”
• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, positive): “Prior to 2000, the attributable mortality of CDI was low, with death as a direct or indirect result of infection occurring in 2% of cases [42–45].”
• Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises (2006, background): “breaks, such as ribotype 027/NAP1 [1–7], it has become”
• Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity (2004, result): “Recent reports suggesting that CDAD might be evolving into a more severe disease included small numbers of patients and did not adjust for age or other confounding factors.(10,11) Our series documented convincingly an increase in the case-fatality rate of CDAD over the study period, even if some pat”
• European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. (2014, background): “Clostridium difficile infection without signs of severe colitis in patients with greater age (≥65 years), serious comorbidity, Intensive Care Unit (ICU) admission, or immunodeficiency may also be considered at increased risk of severe CDI [30,31].”
• Clostridium difficile Infection in Patients Discharged from US Short-stay Hospitals, 1996–2003 (2006, background): “Depending on where the earliest outbreaks caused by this epidemic strain were reported, the higher overall rates in the northeastern United States may reflect the early spread of this strain (9,10,28,29).”
• Narrative Review: The New Epidemic of Clostridium difficileAssociated Enteric Disease (2006, background): “There were also other reports of C. difficile causing more disease and more serious disease in the United States (70, 71) and in other areas of the world (72).”