Electrical synapses and their functional interactions with chemical synapses

By A. Pereda. Nature Reviews Neuroscience, 2014

696 citations recorded by the source corpus.

Brain function relies on the ability of neurons to communicate with each other. Interneuronal communication primarily takes place at synapses, where information from one neuron is rapidly conveyed to a second neuron. There are two main modalities of synaptic transmission: chemical and electrical. Far from functioning independently and serving unrelated functions, mounting evidence indicates that these two modalities of synaptic transmission closely interact, both during development and in the adult brain. Rather than conceiving synaptic transmission as either chemical or electrical, this article emphasizes the notion that synaptic transmission is both chemical and electrical, and that interactions between these two forms of interneuronal communication might be required for normal brain development and function.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/2834c3bfdc296187542644e675d579055029c3d2

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Bin Feng
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Zehua Li

Citations in the corpus

Artificial Intelligence Meets Flexible Sensors: Emerging Smart Flexible Sensing Systems Driven by Machine Learning and Artificial Synapses (2023, background): “This binding of the receptor to the neurotransmitter leads to the opening or closing of the ion channel, which alters the neuronal membrane potential and subsequently generates an electrochemical signal [67].”
Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation (2024, unknown): “Brain function relies on the ability of neurons to communicate with each other, which occurs via electrical and chemical signals (Pereda 2014).”