Adenoma detection rate and risk of colorectal cancer and death.
By M. Dawwas. New England Journal of Medicine, 2014
1,090 citations recorded by the source corpus.
n engl j med 370;26 nejm.org june 26, 2014 2539 tyrosine kinase related to ALK. In fact, previous work established that ceritinib targets both ALK and ROS1 at clinically relevant concentrations, although ceritinib has more potency against ALK.1,2 In ROS1-rearranged NSCLC, resistance to crizotinib may develop owing to the acquisition of a secondary mutation, such as ROS1 G2032R.3 On the basis of the crystal structure of the nonmutant ROS1 kinase domain bound to crizotinib, the substitution of glycine with the bulkier arginine at position 2032 is predicted to cause steric interference with crizotinib binding.3 We speculate that this arginine would also clash sterically with ceritinib, preventing effective binding and inhibition of the kinase. Consistent with this notion, the analogous mutation in ALK (G1202R) causes resistance to ceritinib,4 and in cell-based assays performed in our laboratory, ceritinib is 5 to 10 times less active against ROS1 G2032R than against nonmutant ROS1. Thus, although ceritinib could have activity in ROS1-rearranged NSCLC, we believe that its efficacy would be impaired by the ROS1 G2032R mutation.
Subfields: Oncology, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/2820336f622ba706a5ce56448c56ad1b03df838b
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Citations in the corpus
- Quality Indicators for Colonoscopy (2015, background): “Certainly, the terminology is confusing (eg, had another colonoscopy with negative results, left the health care system, or were diagnosed with CRC.”
- Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model (2017, background): “13 14 Accordingly, different initiatives were developed to investigate cost-effective approaches to derive qualitative histological information from endoscopic images, also referred to as optical biopsy.”
- ACG Clinical Guidelines: Colorectal Cancer Screening 2021. (2021, background): “ADR has been validated as a predictor of cancer occurring after colonoscopy in 3 landmark studies (146,152,156).”