Positive and negative selection on the human genome.

By Justin C. Fay, Gerald J. Wyckoff, Chung-I Wu. Genetics, 2001

627 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2818fbfbb17858b5775aa37e2b73883159daf166

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Citations in the corpus

Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome (2008, result): “’s [8] estimate that 35% of human-chimp nonsynonymous fixed differences were adaptively driven, but contrast with recent calculations suggesting essentially none of these differences were driven by positive selection [35,36].”
The Genetics and Genomics of Plant Domestication (2017, background): “However, because many mutations are only mildly deleterious, they may persist for many generations, similar to mutations that have no effect on fitness (Fay et al. 2001).”
The amino-acid mutational spectrum of human genetic disease (2003, background): “We note that the mutation rate we estimate (a fraction of newly created deleterious mutations) is different from the fraction of existing SNPs with deleterious effects on protein function (estimated previously [1,2,23]).”
Evolution on the X chromosome: unusual patterns and processes (2006, background): “If a substantial fraction of DNA-sequence divergence for non-synonymous mutations is driven by the fixation of beneficial mutations by natural selection ( positive selection ), as has been claimed for mammal”
Adaptive protein evolution in Drosophila (2002, unknown): “The proportion of adaptive mutations can be estimated by a simple extension of the McDonald–Kreitman tes”
Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans (2017, background): “The test is based on the idea that a favorable allele will on average segregate at higher frequency compared to neutral alleles, and neutral alleles will in turn segregate at higher frequencies compared to deleterious alleles [29].”
Impact of selection, mutation rate and genetic drift on human genetic variation. (2003, background): “detected high levels of deleterious SNPs in the human population (4, 16, 29-34 ) here we”
Neutral and weakly nonneutral sequence variants may define individuality (2013, result): “This ﬁ nding is in line with the notion of variant purifying selection (28, 29).”
Interrogating a high-density SNP map for signatures of natural selection. (2002, methodology): “We used coalescent theory (Fu and Li 1999) to obtain the genome-wide distribution of FST under a selectively neutral model.”