TACE is required for fetal murine cardiac development and modeling.
By W. Shi, Hui Chen, Jian Sun, S. Buckley, Jingsong Zhao, K. Anderson, Robertag . Williams, D. Warburton. 2003
122 citations recorded by the source corpus.
Tumor necrosis factor-alpha converting enzyme (TACE) is a membrane-anchored, Zn-dependent metalloprotease, which belongs to the ADAM (a disintegrin and metalloprotease) family. TACE functions as a membrane sheddase to release the ectodomain portions of many transmembrane proteins, including the precursors of TNFalpha, TGFalpha, several other cytokines, as well as the receptors for TNFalpha, and neuregulin (ErbB4). Mice with TACE(DeltaZn/DeltaZn) null mutation die at birth with phenotypic changes, including failure of eyelid fusion, hair and skin defects, and abnormalities of lung development. Abnormal fetal heart development was not previously described. Herein, we report that TACE(DeltaZn/DeltaZn) null mutant mice by late gestation exhibit markedly enlarged fetal hearts with increased myocardial trabeculation and reduced cell compaction, mimicking the pathological changes of noncompaction of ventricular myocardium. In addition, larger cardiomyocyte cell size and increased cell proliferation were observed in ventricles of TACE(DeltaZn/DeltaZn) knockout mouse hearts. At the molecular level, reduced expression of epidermal growth factor receptor, attenuated protein cleavage of ErbB4, and changes in MAPK activation were also detected in TACE(DeltaZn/DeltaZn) knockout heart tissues. The data suggest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regulatory role during cardiac development and modeling.
Subfields: Cardiology and Cardiovascular Medicine, Immunology and Allergy, Molecular Biology
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In Immunology and Allergy
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Citations in the corpus
- ADAMs: key components in EGFR signalling and development (2005, background): “, thickened and misshapen heart valves that resemble those of mice lacking HB-EG”
- The Lack of ADAM17 Activity during Embryonic Development Causes Hemorrhage and Impairs Vessel Formation (2010, unknown): “neuronal tissues [5] but also exhibit impaired heart and lung morphogenesis [6,7] that were postulated to be responsible for the premature mortality.”
- The ADAM metalloproteinases (2008, background): “In particular, HB-EGFÀ/À mice die before weaning with defects in valvulogenesis in the heart and hypoplastic, poorly differentiated lungs that parallel those seen in Adam17À/À mice (Jackson et al., 2003; Shi et al., 2003; Zhao et al., 2001 ).”