Comparison of the photoluminescence properties of semiconductor quantum dots and non-blinking diamond nanoparticles. Observation of the diffusion of diamond nanoparticles in living cells
By O. Faklaris, D. Garrot, F. Treussart, V. Joshi, P. Curmi, J. Boudou, T. Sauvage. 2009
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Long-term observations of photoluminescence at the single-molecule level were until recently very diffcult, due to the photobleaching of organic ?uorophore molecules. Although inorganic semiconductor nanocrystals can overcome this diffculty showing very low photobleaching yield, they suffer from photoblinking. A new marker has been recently introduced, relying on diamond nanoparticles containing photoluminescent color centers. In this work we compare the photoluminescence of single quantum dots (QDs) to the one of nanodiamonds containing a single-color center. Contrary to other markers, photoluminescent nanodiamonds present a perfect photostability and no photoblinking. At saturation of their excitation, nanodiamonds photoluminescence intensity is only three times smaller than the one of QDs. Moreover, the bright and stable photoluminescence of nanodiamonds allows wide field observations of single nanoparticles motion. We demonstrate the possibility of recording the tra jectory of such single particle in culture cells.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/27ebaca526c0319c9edd9bad8fcae9e40c619119
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In Biomedical Engineering
In Materials Chemistry
Citations in the corpus
- Diamond-based single-photon emitters (2011, background): “003 to 1 μm2 s−1 have been reported in the literature for NDs incorporated in live HeLa cells [166, 167, 169].”
- Diamond for bio-sensor applications (2007, background): “These colour centres are resistant against photobleaching and can be up-taken by mammalian cells with minimal cytotoxicity [95, 100].”