Mutational signatures associated with tobacco smoking in human cancer

By Ludmil B. Alexandrov, Y. Ju, Kerstin Haase, P. van Loo, Iñigo Martincorena, S. Nik-Zainal, Y. Totoki, Akihiro Fujimoto, H. Nakagawa, T. Shibata and 4 more. Science, 2016

980 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/278d2fc1e2170475e68e7ec7e76be684e68ea0ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Sowell
2. S. Kaech

In Molecular Biology

1. Edwin Cuppen
2. Roel Janssen
3. David L. Rimm
4. R. Sowell
5. S. Kaech
6. Francis Blokzijl
7. Joseph Schlessinger
8. R. van Boxtel

In Oncology

1. I. Melero
2. David L. Rimm
3. R. Sowell
4. S. Kaech
5. Joseph Schlessinger
6. M. Sanmamed
7. R. Roskoski
8. Jeffrey L. Wrana

Citations in the corpus

• Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer (2017, background): “Our analysis revealed that in the majority of the tumor specimens the dominant mutation signatures were those associated with smoking, APOBEC mutations and to a lesser extent alkylating agents (26,27) (Supplementary Fig.”
• MutationalPatterns: comprehensive genome-wide analysis of mutational processes (2016, background): “Some mutational signatures could be linked to specific biological processes through association with exposure to carcinogens, such as tobacco smoke [6, 7], or the deficiency of DNA repair processes, such as nucleotide excision repair (NER) [8].”