Autophagy in healthy aging and disease
By Yahyah Aman, Tomás Schmauck-Medina, M. Hansen, Richard I. Morimoto, Anna Katharina Simon, I. Bjedov, K. Palikaras, A. Simonsen, T. Johansen, Nektarios Tavernarakis and 5 more. Nature Aging, 2021
1,053 citations recorded by the source corpus.
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health. This Review synthesizes recent research on the mechanisms and roles of autophagy in health, aging and disease and discusses how drugs that modulate the process of autophagy could be used to suppress age-associated diseases.
Subfields: Epidemiology
View Paper: https://www.semanticscholar.org/paper/277ae17d014a7a18cc7a59ec4f9581a58734e6a1
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Citations in the corpus
- Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “220,221 It primarily occurs via three types: micro-autophagy, chaperone-mediated autophagy, and macroauto-phagy (commonly referred to as autophagy).”
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “There is increasing evidence that autophagic activity decreases with age in different tissues in different species.25,122 Lysosomal protein hydrolysis is reduced during aging, which impairs autophagy, exacerbates cellular damage, and promotes the development of age-related diseases.123 For example, ”
- The mitophagy pathway and its implications in human diseases (2023, background): “346,349,356 NAD + activates mitophagy to remove damaged mitochondria and restore the mitochondrial network, inhibiting premature aging and prolonging the lifespan.”