Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses

By R. Bruno, Bert J. Sakmann. Science, 2006

739 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/2763f2799887e11454a62ee602d3c03090d5aeb5

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

In Vivo Measurement of Cell-Type-Specific Synaptic Connectivity and Synaptic Transmission in Layer 2/3 Mouse Barrel Cortex (2015, neutral): “…synaptic transmission between identified neocortical neurons in vivo, presumably due to the technical difficulties in obtaining intracellular recordings from connected pairs of neurons in vivo (Matsumura et al., 1996; Crochet et al., 2005; Bruno and Sakmann, 2006; Yu and Ferster, 2013).”
Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding (2010, background): “Finally, thalamic projections onto layer IV neurons in the somatosensory cortex of rodents were found to be weak, such that only synchrony among the thalamic afferents could reliably elicit a response in the sensory corte”
Synaptic and network mechanisms of sparse and reliable visual cortical activity during nonclassical receptive field stimulation. (2010, background): “…Elsevier Inc. 107 potentials depends critically upon the connectivity and activity levels of presynaptic excitatory and inhibitory neuronal subtypes (Azouz et al., 1997; Bruno and Sakmann, 2006; Contreras and Palmer, 2003; Silberberg and Markram, 2007; Swadlow, 2003; Yoshimura and Callaway, 2005).”
In Vivo Monosynaptic Excitatory Transmission between Layer 2 Cortical Pyramidal Neurons (2015, background): “, 2008; ReidandAlonso, 1995;SwadlowandGusev,2002), a combination of extracellular and intracellular recordings (Bruno and Sakmann, 2006; London et al., 2010;Matsumura et al., 1996; Yu and Ferster, 2013), or sharp microelectrode recordings (Crochet et al.”
Inhibitory Stabilization of the Cortical Network Underlies Visual Surround Suppression (2009, background): “Lateral inhibition may thus be implemented through a network mechanism that leads to a reduction in local recurrent excitation together with a paradoxical decrease in synaptic inhibition, rather than the expected increase in inhibition.”
The functional organization of the barrel cortex. (2007, background): “Strong GABAergic feedback from the reticular nucleus to the thalamus prevents prolonged depolarization of the VPM neurons and sharpens the timing of sensory input to the cortex (Brecht and Sakmann, 2002; Bruno and Sakmann, 2006).”
Spectral fingerprints of large-scale neuronal interactions (2012, background): “Evidence suggests that this is the case: synchronous presynaptic spikes are more effective in driving postsynaptic cortical neurons than non-synchronized input”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “L4 and L5 distributions are compared against in vivo data (L4, dashed red line, left; Bruno and Sakmann, 2006; L5, star dashed red line; Constantinople and Bruno, 2011).”
Cellular and neurochemical basis of sleep stages in the thalamocortical network (2016, result): “It triggered a transient increase of firing in cortical PY neurons and INs, after which the network returned to the baseline, as observed in experiments with a sensory input during alert awake conditions (Bruno and Sakmann, 2006; Hengen et al., 2016).”