Molecular aspects of bacterial pH sensing and homeostasis
By T. A. Krulwich, G. Sachs, E. Padan. Nature Reviews Microbiology, 2011
984 citations recorded by the source corpus.
Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must maintain for growth. The most extreme cases are exemplified by the extremophiles that inhabit environments with a pH of below 3 or above 11. Here, we describe how recent insights into the structure and function of key molecules and their regulators reveal novel strategies of bacterial pH homeostasis. These insights may help us to target certain pathogens more accurately and to harness the capacities of environmental bacteria more efficiently.
Subfields: Environmental Engineering, Molecular Medicine, Plant Science
View Paper: https://www.semanticscholar.org/paper/276359072c2e26703817ea2e21b8760fd202df52
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Citations in the corpus
- Study of pH Changes in Media during Bacterial Growth of Several Environmental Strains (2018, background): “Bacterial pH-homeostasis include diverse mechanism for direct sensing and adapting to extracellular pH [2].”
- The pH of Enceladus’ ocean (2015, background): “To prevent these deleterious effects, alkaliphilic organisms have evolved biochemical adaptations (e.g., Na+/H+ antiporters) to keep their cytosolic pH near neutral, despite the high external pH (Krulwich et al., 2011).”