The role of protein clearance mechanisms in organismal ageing and age-related diseases

By D. Vilchez, Isabel Sáez, A. Dillin. Nature Communications, 2014

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Metabolic Control of Longevity. (2016, background): “Signaling pathways that impinge on intermediate metabolism and regulate proteostasis influence aging as well as the onset and progression of age-related diseases (Vilchez et al., 2014).”
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein (2015, positive): “The age-dependence of prion diseases, and neurodegenerative diseases more generally, may be the result of a decrease in the efficiency of protein quality-control systems (35).”