Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

By N. Rajamannan, M. Subramaniam, D. Rickard, Stuart R. Stock, Janis L. Donovan, M. Springett, T. A. Orszulak, D. Fullerton, A. Tajik, R. Bonow and 1 more. Circulation, 2003

754 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Nephrology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/275aa521f38a789c980fd71ea1d62e25a7b47fd2

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1. M. Dweck
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5. A. Liu
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Citations in the corpus

• Calcific aortic stenosis: a disease of the valve and the myocardium. (2012, background): “Osteoblasts subsequently coordinate calcification as part of a highly regulated process, akin to new bone formation (33), with the local production of many factors more commonly associated with skeletal bone metabolism, including osteopontin, osteocalcin, bone sialoprotein, and bone morphogenic prot”
• The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. (2007, background): “Mechanistic studies suggest that BMP2 can up-regulate both an osteogenic pathway involving the transcription factor Msx2, which activates Wnt signaling, and a chondro-osteogenic pathway involving the transcription factor Runx2/Cbfa1,(60) which is increased in aortic valves of hypercholesterolemic ra”