Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease.

By G. Anderson. The Lancet, 2008

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Epidemiology of Asthma in Children and Adults (2019, background): “A consolidated definition of asthma may not be desirable given the emerging consensus in the research community that “asthma” is an umbrella term for several diseases with similar clinical manifestations but different underlying pathophysiological mechanisms (5), often referred to as “asthma endotyp”
T-helper type 2-driven inflammation defines major subphenotypes of asthma. (2009, background): “These findings are timely in that they provide a mechanistic framework for the emerging clinical observation that asthma is a complex and heterogeneous disease (26).”
Clustering Longitudinal Clinical Marker Trajectories from Electronic Health Data: Applications to Phenotyping and Endotype Discovery (2015, background): “When such traits have been linked to a distinct underlying pathobiological mechanism, these are then referred to as endotypes (Anderson 2008).”
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients (2012, methodology): “Comparison of sample matrices—Blood was obtained by means of venipuncture from 10 healthy subjects using 4 typical clinical specimen tubes for each donor: (1) serum, (2) plasma anticoagulated with EDTA, (3) plasma anticoagulated with sodium citrate, and (4) plasma anticoagulated with heparin.”