Defining ‘T cell exhaustion’

By Christian U. Blank, W. Nicholas Haining, Werner Held, Patrick G. Hogan, Axel Kallies, E. Lugli, Rachel C. Lynn, M. Philip, Anjana Rao, N. Restifo and 8 more. Nature reviews. Immunology, 2019

1,291 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/274811963302a099e4cabd7b6e567f263680c106

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In Immunology

1. M. Hellmann
2. A. Schoenfeld

In Oncology

1. M. Hellmann
2. A. Schoenfeld

Citations in the corpus

• Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion (2021, neutral): “Compared to LN-resident Pmel-1 T cells, tumor-resident, gp100-restimulated T cells were far less polyfunctional 12,21 (Fig.”
• Acquired Resistance to Immune Checkpoint Inhibitors (2020, background): “Although such checkpoints may in some contexts be functionally associated with T cell exhaustion and terminal dysfunction, they may also be associated with T cell activation (Blank et al., 2019).”