Postsynaptic signaling during plasticity of dendritic spines
By H. Murakoshi, R. Yasuda. 2012
168 citations recorded by the source corpus.
Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal dendrites, have been thought to serve as basic units of memory storage. Despite their small size (~0.1 femtoliter), thousands of species of proteins exist in the spine, including receptors, channels, scaffolding proteins and signaling enzymes. Biochemical signaling mediated by these molecules leads to morphological and functional plasticity of dendritic spines, and ultimately learning and memory in the brain. Here, we review new insights into the mechanisms underlying spine plasticity brought about by recent advances in imaging techniques to monitor molecular events in single dendritic spines. The activity of each protein displays a specific spatiotemporal pattern, coordinating downstream events at different microdomains to change the function and morphology of dendritic spines.
Subfields: Cellular and Molecular Neuroscience, Materials Chemistry, Molecular Biology
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Citations in the corpus
- Astrocytes Control Synapse Formation, Function, and Elimination (2015, unknown): “TNF-a KO mice show normal hippocampal LTP and LTD (Stellwagen and Malenka 2006).”
- The synaptic plasticity and memory hypothesis: encoding, storage and persistence (2014, background): “Recent reviews of the persistence of LTP/LTD collectively point to the importance of translational control of dendritic mRNAs, and that spine dynamics may be remarkably fast to be in register with the relatively immediate functional changes [9–11].”