Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

By M. Kazui, Y. Nishiya, T. Ishizuka, K. Hagihara, N. Farid, O. Okazaki, T. Ikeda, A. Kurihara. Drug Metabolism And Disposition, 2010

815 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Pharmacology

View Paper: https://www.semanticscholar.org/paper/26dcf71c4fb16381062a467b5fc7bc25861d538c

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In Pharmacology

1. M. Schwab
2. Ulrich M. Zanger

Citations in the corpus

• Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “The CYP2C19 enzyme was later shown to be the major enzyme for the inactivating metabolism of proton pump inhibitors (PPI) including omeprazole and pantoprazole, and for the metabolic activation of the anticoagulant clopidogrel to the active 2-oxo metabolite (Hulot et al., 2006; Kazui et al., 2010; D”