Chromatin accessibility and the regulatory epigenome

By Sandy L. Klemm, Zohar Shipony, W.J. Greenleaf. Nature reviews genetics, 2019

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Obtaining genetics insights from deep learning via explainable artificial intelligence (2022, background): “…from which rNa transcription is initiated, and distal regulatory elements such as enhancers, which confer patterns of specificity upon promoters 88,89 . owing to the crucial role of gene regulation in controlling the phenotype of cells 90 , new technologies for measuring cellular properties…”
Gene regulatory network inference in the era of single-cell multi-omics (2023, background): “involve regions of intermediate accessibility that fluctuate in a dynamic manner 159 .”
Measuring biological age using omics data (2022, background): “This may, in large part, be due to the complexity and noise in bulk chromatin accessibility and chromatin conformation capture assays, which are strongly affected by cell composition differences between samples and other batch effects 138–141 .”