Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin‐12

By C. Yoon, S. Johnston, Jin Tang, M. Stahl, J. Tobin, W. Somers. 2000

159 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Immunology, Radiology, Nuclear Medicine and Imaging

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Scheller
2. Rhiannon Morris
3. J. Babon
4. N. Kershaw

In Radiology, Nuclear Medicine and Imaging

1. J. Scheller

Citations in the corpus

• Non-Canonical Interleukin 23 Receptor Complex Assembly (2014, background): “IL-23 is a disulfide-linked composite cytokine comprising p19 and p40 (8). p19 belongs to the gp130 class of long-chain cytokines, and the p40 subunit is similar in the domain structure of typical class I cytokine receptors, such as the non-signaling IL-6 receptor (IL-6R) (9).”
• The molecular details of cytokine signaling via the JAK/STAT pathway (2018, methodology): “IFNαR1 has a large extracellular domain that consists of two CHRs while IFNαR2, similar to all other Class II cytokine receptors has only a single CHR. IFNαR2 is the high affinity chain, interacting with ligand with sub-nanomolar affinity whilst IFNαR1 binds with an affinity approximately two orders”
• Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex (2017, background): “Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor.”