Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display.

By D. Steiner, P. Forrer, A. Plückthun. 2008

263 citations recorded by the source corpus.

Subfields: Ecology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. David Baker
2. David R. Liu
3. I. Samish

In Molecular Biology

1. David Baker
2. Gaetano T. Montelione
3. Gaohua Liu
4. John Karanicolas
5. I. Samish
6. J. Corn
7. L. Joachimiak
8. Tanja Kortemme

In Radiology, Nuclear Medicine and Imaging

1. John Karanicolas
2. David Baker
3. I. Samish
4. Frances H. Arnold

Citations in the corpus

• Programmable protein delivery with a bacterial contractile injection system (2023, positive): “To test this, we inserted a novel binding domain specific for human cells (the trimeric knob domain from human adenovirus 5 (Ad5) 38 or the epidermal growth factor receptor (EGFR)-specific designed ankyrin repeat protein (DARPin) E01 39 ) into the putative C-terminal binding region of Pvc13 (to gene”
• A de novo protein binding pair by computational design and directed evolution (2011, background): “Given multiple reports of AR proteins selected for binding to a variety of target proteins for which they initially had no natural affinity (Steiner et al., 2008), we wished to exclude the possibility that affinity maturation of Pdar would induce it to bind to a new surface of Prb.”