Tissue Doppler Imaging Consistently Detects Myocardial Abnormalities in Patients With Hypertrophic Cardiomyopathy and Provides a Novel Means for an Early Diagnosis Before and Independently of…

By Sherif F. Nagueh, L. Bachinski, Denise Meyer, R. Hill, W. Zoghbi, J. Tam, M. Quiñones, R. Roberts, A. Marian. Circulation, 2001

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American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice G (2003, background): “Furthermore, novel diagnostic criteria for HCM have recently emerged, based on genotype-phenotype studies showing that incomplete penetrance and disease expression with absence of (or minimal) LVH may occur in adult individuals (most commonly due to cardiac myosin-binding protein-C or troponin-T mut”
Hypertrophic cardiomyopathy: a systematic review. (2002, background): “Abnormalities on 12lead ECG and non–preload-dependent measures of diastolic dysfunction with tissue Doppler ultrasonography may precede the appearance of hypertrophy, providing clues to impending LVH.(25,29,51,54,56,58,59)”
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy. (2017, background): “such as reduced tissue Doppler velocities, and elevated serum biomarkers.(191,225,226) Given the age-related penetrance of the mutation, many mutation carriers/phenotype-negative rela-”