Subunit counting in membrane-bound proteins

By Maximilian H. Ulbrich, E. Isacoff. Nature Methods, 2007

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Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “…reduced compared with current from GluN1/GluN2, suggesting that either triheteromeric GluN1/GluN2/ GluN3 receptors form that have a lower conductance, or GluN3 expression reduces trafficking or assembly of GluN1/GluN2 (Das et al., 1998; Perez-Otano et al., 2001; Ulbrich and Isacoff, 2007, 2008).”
Handbook of ion channels (2015, methodology): “Two labs applied the subunit-counting approach wherein channel stoichiometry is evaluated by counting the number of photo-bleach steps of GFP fused to ORAI1 monomers [111].”
The Influenza A Virus PB2, PA, NP, and M Segments Play a Pivotal Role during Genome Packaging (2012, methodology): “Colocalization between Cy3 and Cy5 images was analyzed similarly to what was previously described (16, 33).”